Cardiovascular, Renal, Gastrointestinal, Respiratory and Haemopoietic Pharmacology

Non selective B adrenergic blockers have the following disadvantages EXCEPT

Which of these is not true about Beta-2 stimulation?

B-adrenergic receptor antagonists may lower blood pressure by other mechanism except

B2 agonists and methylxanthines

B2 agonists, UNTRUE statement

These lipoprotein particles transport fat from digestive tract to the liver

The following statements concerning the diuretic acetazolamide are correct except

The following are the characteristics of Osmotic diuretics except

Mannitol can be used in the management of the following conditions except

Loop diuretics produce the following actions except

Adverse effects associated with loop diuretics include all except

The second generation antihistamines are newer, more novel agents. Which is false concerning their pharmacology? ·

Massive histamine release can be precipitated by all following except

Warfarin, which is false

Coumarin derivatives

Unlike WARFARIN, Heparin

Which of the following is not an adverse effect of Heparin

Proton pump inhibitors

Anti-ulcer agents

There is no compelling reason to favour one ACE Inhibitor over another because

ACE inhibitors in left ventricular systolic dysfunction

Angiotensin receptor blockers (ARBS) inhibit all of the following angiotensin induced and other effects except.. [al contraction of vascular smooth muscle

The mechanism of action of Nitroso compounds as antiangina agents involves all of the following except

High doses of nitro the following effects except

Ca2+ channel antagonists

Ca2+ channel antagonists

Ca2+ channel blockers

Select the most correct statement

Aldosterone antagonists

Which of the following is a statement true Clofibrate?

Arrhythmias could be due to all the following EXCEPT?

All of the following are moderate phase O depression antiarrhythmic agents EXCEPT

Organic nitrates, FALSE statement

Concerning Minoxidil which of the following statement is WRONG?

Which is FALSE concerning antihyperlipidaemic agents?

H2 blockers attenuate the gastric acid secretory response by one of the following mechanisms

Major difference between the mechanism of action of PPIs and H2 receptor antagonists (HRA)

Which Statement concering methylxanthines and the treatment of asthma is FALSE?

Methylxanthines, WRONG statement

Steroids, INCORRECT statement

Bronchial asthma, INCORRECT statement

Which is FALSE concerning bile acid vessels binding resins?

Which is INCORRECT concerning ACEIS carefully avoided

CORRECT statement about lipoproteins

Which is FALSE about anti-asthma agents

Warfarin, which is TRUE

Warfarin, INCORRECT statement

Warfarin, INCORRECT statement

Warfarin, INCORRECT statement

Warfarin action, INCORRECT statement

Warfarin, incorrect statement

Heparin, INCORRECT statement

Concerning Phosphodiesterase inhibitors inhibition

WRONG statement concerning Misoprostol

Which is FALSE concerning agents used in the management of peptic ulcer?

Which of this is NOT TRUE of statins?

FALSE statement concerning digitalis

Concerning Digoxin, all of the following statements are true EXCEPT

Which of these agents are more likely to affect the cytochrome P450 drug metabolizing system?

INCORRECT statement concerning the mechanism of action of digitalis

INCORRECT statement concerning the mechanism of action of digitalis

Pathophysiology of heart failure, WRONG statement

Which is false concerning unfractionated heparin and low molecular weight heparin

Concerning Direct inhibitors of factor 10a, which is CORRECT

Gastric acid secretion is influenced by the following agents?

Which of the following is FALSE?

H2 blockers attenuate the gastric acid secretory response by one of the following mechanisms?

Concerning Direct inhibitors of factor 10a, which is INCORRECT

WRONG statement concerning treatment

Antihypertensive with hem of he schin as while effect online

Antihypertensive used topically to treat Alopecia include A Hydralazine

Antihypertensive ociated with First Dec phenomenon

Concerning the pharmacologic actions of glucocorticoids which statements is UNTRUE

The mechanism of the anti-inflammatory and immunosuppressive actions of glucocorticoids include all the following EXCEPT

Possible side effects of glucocorticoids include the following EXCEPT

Which of the following statements concerning therapy with glucocorticoids is TRUE?

Which one of the following medication major side effect combination is NOT correct? A Toluclin-High blood pressure

Which of the following statements about celecoxib is true?

The main clinical uses of NSAIDS include the following except

Which one of the following medications is best for treating patients with myocardial infarction?

The rational for the use of NSAIDs in primary dysmenorrhea is A Dysmenorrhea is an inflammatory process

The False statement NSAID)

Classification of Antiarrhythmic Drugs, False statement

Angiotensin II causes rise in blood pressure by the following except

The following factors enhance Renin release from the Kidney except

Potentiation of bradykinin appears to play a role in the following effects of Angiotensin Converting Enzyme Inhibitors except

Which of the following antihypertensive is indicated in a hypotensive with BPH7

Within the cardiac myocyte, Tropinin

Concerning calcium channel antagonist

Pathophysiology of heart failure includes

Agents that affect cardine renmiddelling

In normal cardiac cells, the NA+K+ ATPase exchanges

Suitable for the treatment of digitalis induced arrhythmias

Which of the underlisted drugs will not enhance the release of vasopressin

The antidiuretic action of vasopressin can be enhanced by all the following except

An agent that does not promote persistent reflex

Inclusion of ineclofenuate to the medication of a patient on warfarin resulted in pronounced hemorrhage. This may have resulted from

Eicosanoids can be derived from the following except

Which of the drugs below is useful in peptic ulcer and in the induction of labour?

The antipyretic effects of NSAIDs can be stimulated to these

Nephrotoxicity is a major adverse effect of which of the following immunosuppressive agents

Which of the following immunosuppressive agents is LEAST likely to suppress bone marrow functions A Castionecr

All of the following agents are useful in treating autoimmune disease Disease EXCEPT A Azathioprine

Which of the following will not combine to the inflammatory response?

Which of the underlisted drugs induced immunosuppression by interfering with nucleic acid metabolism of phil cells?

The primary cells that are involved in the first line of defense by the body against antigenic challenge are A Neutrophils

Digitalis must be used with caution in patients with acute myocardial infarction. Which of the following is true of digitalis use?

Which of the following is NOT an indication for ẞ blocker therapy?

A group of college students is planning a mountain climbing trip. Which of the following drugs would be appropriate for them to take to prevent mountain sickness

The main principles underlying multidrug therapy of hypertension (EXCEPTION)

The LEAST rational combination of agents for treatment of hypertension resistant to monotherapy with \"firstline\" drugs

Antihypertensive agent must be used with caution. Choose the medical condition for which methyldopa is most contraindicated from the list below

Which of the following drugs is usually employed in familial hypercholesterolemia?

Which of these is not true of HDL?

Lipid lowering drug useful in the management of pruritus due to biliary obstruction?

Which of the following is not a class 1 anti-arrhythmic agent

The best drug to use in long term control of chronic asthma would be

Nitrates, CORRECT statement

Class of gastrointestinal drugs that decreases intragastric acidiy whilst contributing eradication of H. pylori

Antiemetic that could precipitate extra pyramidal symptoms

Mechanism of action of antimicrobial activity against H. pylori cytoprotection binds to the ulcer base

Which of the following is not an action of corticosteroids?

Drug better suited for the management of cytokine induced asthma

Which of these drugs is not an anti-inflammatory?

Which of these statement is not true about ẞ-2 stimulation?

Preferred pre-exercise class of drug for an asthmatic

Anti-arrhythmic agents, INCORRECT statement

B-blocker FALSE statement

A 74yrs man on warfarin was doing well until proxicam was included in his medication to control his toothache. Patient suddenly started bleeding and developed pedal oedema. What may be responsible for the bleeding?

Which of the following is not an adverse effect of Heparin?

Heparin, INCORRECT statement

Unlike warfarin, Heparin

Unlike heparin, warfarin

Mechanism of warfarin action INCORRECT statement

Warfarin INCORRECT statement

Which of the following lipid lowering drugs can be used in the treatment of pruritus caused by biliary obstruction

Warfarin, INCORRECT statement

Warfarin, INCORRECT statement

Warfarin, INCORRECT statement

Diuretics CORRECT statement

Inhibitors of Na+/Cl-symport include all EXCEPT

Which of the general statement is TRUE

Propranolol may cause all of the following EXCEPT

Anti-Anythmic agents, INCORRECT statement

The principal action of organic n treatment of congestive heart failure

B-blockers, FALSE statement

A 74 year old man or warfarin was doing well until piroxicam was included in his medication to control his toothache. Salient suddenly started bleeding and developed pedal edema. What may be responsible for the bleeding?

Heparin, INCORRECT statement

Which of these antiemetics act via central dopaminergic blockade symptoms extra

Which of these is not a mucosal drug?

Antacid: effective, but associated with osmotic diarrhea

Side effect profile - antiulcer medication depression, bradycardia, gynecomastia, Muscle pain and constipation

Anti-emetic that could precipitate extra pyramidal symptoms

Mechanism of action antimicrobial activity against H. pylori cytoprotection, binds to the ulcer base

An agent that does not promote peristatic reflex

All of the following decrease gastric motility except

The following are cardiac depressants useful in angina Except

Alvimopam is indicated in which condition

The dihydropyridine block the following types of calcium channels

In acute attack of angina, the following agent is given sublingually

Concerning Mechanism of ACEIs, which is Incorrect

Hyperuricemia is a common example with which class of Diuretics

Which of these agents are most likely to affect the cytochrome P450 drug metabolizing system?

Which of these antiemetics act via central dopaminergic blockade

Which of these is not a mucosal protective drug?

Methylxanthines are all of the following except

Drugs better suited for the management of aspirin induced Asthma

Mechanism of action of WARFARIN. INCORRECT STATEMENT

Incorrect about WARFARIN

Unlike heparin, WARFARIN

Side effect of Heparin include all EXCEPT

Concerning WARFARIN, which of the following is FALSE

A 78yr old man on WARFARIN took Piroxicam for toothache, later He began to experience hemorrhage. Which of the following explains this?

Which of the following is used in Familial hypercholesterolemia

Which of the following is used to treat long standing Asthma

Select the most correct statement

Side effect profile. Anti ulcer medication, muscle pain, constipation, depression & bradycardia

Anti-emetic with extra pyramidal effect

Which is not true about HDL

Which of the following inhibits cholesterol uptake from enterocytes

What causes osmotic diarrhea

Drugs useful in aspirin induced asthma

Concerning methylxanthines which is FALSE

Which of these will decrease the plasma VLDL & LDL

The lipoprotein that transports cholesterol from Digestive tract to the liver

Cutaneous flushing is caused by;

An anti ulcer that inhibits CYP 450

Drugs with cryoprotectant properties include the following EXCEPT

Which of the following is incorrect concerning WARFARIN therapy

Which lipoprotein causes reverse cholesterol transport

Drugs used to before exercise to prevent asthmatic attack

Which anti emetic has dopamine receptor blocking properties

Which of the following is not a class 1C anti-arrhythmic

Which of the following CCBs has the clearest effect

Drug that decreases H. pylori and acid production

Example of antidiarrhoea drugs include all EXCEPT

Which diuretic causes erectile dysfunction

Which of these inhibits reflex peristalsis

Concerning diuretics

Diuretics, correct statement

Cryoprotectant which decreases intragastric activity and has antimicrobial action

Alpha methyldopa has been used successfully in the control of hypertension. Side effects include all of the following, EXCEPT

Propranolol produces most of its important effects by antagonizing the beta adrenergic effects of catecholamines released by sympathetic nerve stimulation or from the adrenal medulla. It therefore results in all of the following EXCEPT

It is important to understand the side effects of the various antihypertensive agents. Drugs such as guanethidine that block the function of postganglionic adrenergic neurons may produce all of the following EXCEPT

Propranolol is contraindicated in all of the following EXCEPT

Which of the following pairings is incorrect

Incorrect statement about Atropine

Incorrect statement about Propanolol

Antiarrhythmic drugs can be separated into four groups, types I to IV. All of the following are type I antiarrhythmic drugs EXCEPT

Quinidine toxicity includes all of the following EXCEPT

The effect of different antiarrhythmic agents is best understood by knowing their predominant actions on cardiac fibers. All of the following general statements are true EXCEPT

In the pharmacologic treatment of cardiovascular disorders, quinidine has all of the following effects EXCEPT

Which of the following medications is contraindicated in a patient with untreated complete heart block?

TRUE statements concerning Vaughan-Williams\'s Class III antiarrhythmic drugs include all EXCEPT

A class IB antiarrhythmic, characterized by rapid association - dissociation from sodium channels Questions 17 - 20 Choose the correct answer for the following questions from the list below. Each answer can be used once, more than once, or not at all

Incorrect statement about Heparin

Incorrect statement about Warfarin

Which of the following substances has its major activity as a saline cathartic?

The correct statement regarding sucralfate

Correct statement regarding metoclopramide

To induce daily bowel movements in normal healthy individuals

Which of the following substances is most likely to cause systemic alkalosis?

Saline cathartics, such as sodium sulfate or magnesium sulfate

Adverse effect(s) of laxatives

In esophagitis, elevation of the head of the bed, abstinence from ethanol and tobacco, and small frequent meals are all useful adjunctive therapeutic measures. Other useful therapy may include all of the following EXCEPT

Drug which exerts anti-peptic ulcer effects through histamine-2 receptor antagonism

Cimetidine reduces the clearance of all of the following EXCEPT

Which of the following substances has its major activity as an stimulant cathartic?

Which of the following is NOT an indication for B-blocker therapy

A group of college students are planning a mountain climbing trip. Which of the following drugs would be appropriate for them to take to prevent mountain sickness?

Hypertension is a disorder that must be treated with care. Which of the following indication (contraindication) is associated with methyldopa in the treatment of hypertension

Hypertension is a disorder that must be treated with care. Which of the following indication (contraindication) is associated with hydralazine in the treatment of hypertension

Anti-hypertensives must be used with caution, choose the medical condition for which reserpine is most contraindicated

Formed from sequential enzymatic cleavage by rennin and then peptidyl dipeptidase (kinase II)

Lower blood pressure in hypertensive patients by inhibition of peptidyl dipeptidase

The LEAST rational combination of agents for treatment of hypertension resistant to monotherapy with \"first-line\" drugs

Coadministration of statins with all of these class of drugs except one is associated with the increased risk of rhabdomyolysis

Which of these drugs is usually employed in familial hypercholesterolemia

Which of these is not true of HDL

Lipid lowering drugs useful in the management of pruritus due to biliary obstruction

Antihyperlipidemic agents that reduces VLDL and consequently, IDL and LDL lipoprotein plasma levels

Drug of choice for paroxysmal supraventricular tachycardia unresponsive to vagal maneuvers

Produces transient increase in blood pressure followed by hypotension due to initial release of norepinephrine from neurons followed by blockade of norepinephrine re- uptake

Contains iodine in molecular structure, is similar to thyroxine, and use is associated with hyper- or hypothyroidism in 2%-5% of patients

Pharmacokinetic properties characterized by very high protein- binding (99.9%), very large volume of distribution (66L/kg), and average elimination half-life of 25 days

A class IC antiarrhythmic, characterized by high affinity for and slow dissociation from fast sodium channels

A class IB antiarrhythmic, characterized by rapid association- dissociation from sodium channels

A positive Coomb\'s test and haemolytic anaemia may follow the administration of which antihypertensive drug?

In a hypertensive patient who is taking insulin to treat diabetes, which of the following drugs is to be used with extra caution and advice to the patient

Drugs that block the catecholamine uptake process (eg: cocaine, TCADs and phenothiazine) are able to block the antihypertensive action of which of the following drugs

ACEls are associated with high incidence of which of the following adverse reactions

Significant relaxation of smooth of both venules and arterioles is produced by which of the following drugs

Which of the following drugs is NOT used in preterm labor

Which of the following drugs inhibit effect of sympathetic nerve stimulation on blood vessels

Converted to a \"false transmitter\" in noradrenergic nerve terminals, works mostly in the CNS

Inhibition of calcium in vascular smooth muscle

Match the receptor types with their effects Increased cardiac chronotropy (rate) and inotropy (contractility), increased AV node conduction velocity and increase in rennin juxtaglomerular cells

Match the receptor types with their effects: Relaxes smooth muscle and causes liver glycogenolysis and gluconeogenesis

Match the following receptor subtypes with their effects: Vascular smooth muscle contraction and genitourinary system muscle contraction

Match the following receptor subtypes with their effects: Decreases insulin secretion from B-cells, decreases nerve cell norepinephrine release and contracts vascular smooth muscle

Gastric acid secretion is controlled by the following EXCEPT

Which of the following may cause reversible gynaecomastia

Pick an emetic drug of central action

Select the emetic drug with reflex action

Which is the mechanism of action of (stimulant) purgative

Drugs that reduce Cholesterol uptake from enterocytes

Drugs that cause skin flushing as side effect

Which of the lipoprotein aids the reverse transport of cholesterol

Which of the following is a first line drug of choice in severe hypertriglyceridemia in a patient at risk of pancreatitis

Diuretics, correct statement

Inhibitors of Na-Cl symporters are: The question is meant to be expect

Characteristics of osmostic diuretics

Which is the true statement

Which of the following anti-emetic act via central dopaminergic blockade

Agents that does not promote peristaltic reflex

Which of the following antiarrhythmics may worsen angina symptoms by increasing myocardial oxygen requirements?

Cinchonism is a dose-related adverse reaction associated with which of the following antiarrhythmics?

Which of the following are classified as IB antiarrhythmics?

In treating supraventricular arrhythmias, which of the following reduces ventricular response primarily by increasing the effective refractory period of the A-V node?

Class IC antiarrhythmics possess which of the following electrophysiologic properties?

Which of the following is not an action of corticosteroids?

Regarding hyperlipidemia, which of the following can worsen lipid profile intravenously

Urinary incontinence and retrograde ejaculation are side effects of which class of antihypertensive

Main principles underlying multidrug therapy of hypertension (EXCEPTION)

The LEAST rational combination of agents for treatment of hypotension resistant to monotherapy with first-line drugs. have an unacceptably

Antihypertensive agents must be used with caution. Choose the medical condition for which Methyldopa is most

Which of these drugs is usually employed in familial hypercholesterolemia? Colestipol

Which of these is not true of HDL?

Anti-hyperlipidemic agent that reduces VLDL and consequently, IDL and LDL lipoprotein plasma levels

Class of gastrointestinal drugs that decreases intragastric acidity whilst contributing to the eradication of H. pylori

Side effect protic antolcer medication depression, bradycardia, gynecomastia, Muscle pain and constipation

All of the following decrease gastric motility except A Loperamide

Drugs belter suited for the management of aspirin induced Asthma

A 74 yr old man or warfarin was doing well until piroxicam was included in his medication to control his toothache. Palient suddenly started bleeding and developed pedal oedema. What may be responsible for the bleeding?

UNLIKE heparin, Warfarin

Mechanism of warfarin action, INCORRECT statement

Thiazide, TRUE statement

Which of the general statement is TRUE