Central Nervous System Pharmacology and Toxicology

Which of the following is not an indication for the use of Botulinum toxin?

Like the barbiturates, the benzodiazepines

Unlike benzodiazepines, barbiturates

Benzodiazepines, wrong statement

A patient who has been treated with Levodopa is switched to a regimen with a product that contains levodopa + carbidopa. What is the main action of carbidopa that provides the rationale for the combination

Regarding pharmacokinetics of antidepressants

Trihexyphenidyl is prescribed as an adjunct to other drugs being used to manage a patient with Parkinsons disease. What is the most likely purpose or action of this drug as part of the overall drug treatment plan

A boko haram terrorist drops a bomb of nerve gas in a crowded pathway at rush hour. The patients are brought to the nearest Emergency ward and they are given Atropine. Which effect of the nerve gas will persist after giving the atropine?

In patient on Disulfiram, the unpleasant effect of ethanol injection result from

Which of the following statement about Lithium is not correct

Both cocaine and amphetamine

Which of the following statements concerning the use of opioid: for the treatment of diarrhea is UNTRUE

A 66yr old woman is diagnosed with Alzheimer's disease with symptoms being described as mild to moderate. What pharmacologic approach is generally considered the most fruitful in terms of alleviating symptoms in early Alzheimer's and probably slowing the course of the underlying brain pathology

A 400-level medical student is transported to the emergency department. A friend who accompanied the student, says He was experimenting with 'Angel dust' what best describes the action or other characteristics of this recreational drug more properly known as phencyclidine?

A patient with Parkinson's disease has signs & symptoms that can be considered moderate now but they are worsening and not responding well to current drug therapy. The physician decides to empirically assess an anti-parkinson drugs that is a selective inhibitor of MAO-B, What drug will that be?

Which of the following general statements concerning opioids is untrue?

Concerning the pharmacokinetic of opioids, which of the following is true?

The following actions of opioids are mediated by opioid receptors except?

Tolerance occurs to all the effects of opioids except?

Which of the following opioid is not normally administered as an antitussive?

Which of the following statement concerning the pharmacological actions of opioid is untrue?

An agent used for the management of opioid withdrawal because of its high binding activity for meu opioid receptors and its slow dissociation from these receptors is?

Which of the following statement concerning the use of opioids for the treatment of diarrhea is FALSE?

Useful agent for the treatment of neuropathic pain include all the following except

A known drug addict is rushed to casualty in a coma with pinpoint pupils with needle marks on both forearms. The most useful agent to give is?

Which of these drugs will interfere with V-MAT, depleting synaptic vesicles of their neurotransmitter content?

Cocaine exacts its central action by one of these mechanisms

Which of these is true of LSD? (Pages 571 of 12th ed Kartzung)

Methylenedioxymethamphetamaine may be used clinically for all except?

Which of the following analeptics will sufficiently increase tidal volume in chronic lung disease?

Principal effect of the amphetamine include all except?

Useful agents for the treatment of neuropathic pain include all the following EXCEPT

Which of these statements about a microbial toxin is correct?

True statement about depression

Drug treatment for psychosis

Drugs causing psychosis include all except?

Which of the following is used in the management of glaucoma?

Which is characterized by liver necrosis, jaundice, hemorrhage& edema?

Untrue statement

Halothane, untrue statement

Most potent inhalation agent

Local anaestghetic agent, true agent

A patient took a Dopamine agonist that has no effect on dopamine or serotonine receptors

Which is an Ester

Insomnia, preferred drugs include all except

Phenytoin false statement

Drug of choice in absence seizures

A patient who has been treated with Levodopa is switched to a regimen with a product that contains Levodopa plus Carbidopa. What is the main action of Carbidopa that provides the rationale for using it in this dual drug approach

Side effects of Tramadol includes all of the following EXCEPT

A patient with parkinson disease starts therapy with an antiviral drug, which is also used to relief fatigue in multiple sclerosis. It has no direct effect on dopamine synthesis, but appears to be a weak NMDA receptor antagonist. What drug fits this description the best

A 10yrs old boy has nocturnal enuresis. His parents take him to a clinic that specialises in management of this condition. The physician writes an order for a low dose of imipramine. After a couple of weeks on drug, the episode of bedwetting decreased dramatically. What is the most likely mechanism by which the imipramine provided benefit?

A Boko haram terrorist drops a bomb of \'nerve gas\' into a crowded pathway at rush hour. The patients are brought to the nearest Emergency ward and they are given Atropine. Which effect of the nerve gas will persist after giving the atropine?

In patients taking Disulfiram, the unpleasant effect of ethanol injection result from

Which of the opiate receptor subtypes that binds naloxone responsible for reversing respiratory depression and miosis?

A 60yr old woman was diagnosed with alzeihmer with symptoms described as mild to moderate.. What pharmacologic approach is considered the most appropriate In terms of alleviating the symptoms of early alzhemier and probably slowing the course of undergoing brain pathalogy?

A patient with Parkinson\'s disease has signs and symptoms that can be considered moderate now but they are worsening and not responding to current drug therapy. The physician decides to emperically assess an antiparkinson drug that is a selective inhibitor of monoamine oxidase inhibitor type-B( MOA-B)

N-methyl-d-aspartate( NMDA) receptor antagonist

Which of the following general statement concerning opiods is untrue

Concerning the pharmacokinetics of opiods, which statement is true?

The following actions of opioids are mediated by mu-opioid receptors EXCEPT

Chlorpromazine (CPZ)

Which of the following agents possess the greatest pharmacological activity before undergoing biotransformation invivo?

Which of the following statements concerning the pharmacological actions of opioids is untrue?

Which of the following statements concerning the use of opioids for the treatment of diarrhea is UNTRUE?

Useful agents for treatment of neuropathic pain include all of the following except

Which of these drugs will interfere with the vesicular monoamine transporter (VMAT), depleting synaptic vesicles of their neurotransmitter content?

Cocaine exerts its central action by one of these mechanisms

Which of these is true of LSD?

Methylenedioxymethamphetamine may be used clinically for all EXCEPT

Principal effects of amphetamine include all except

Which of the following is not an indication for use of botulinum toxin?

Which of these toxins can be employed in glaucoma management?

Contraindication(s) for Botox

Which environmental health scientist would determine ways to prevent and reduce exposure to hazards in the work place?

A substance with LD50 value of 600mg/kg will be classed as

Which is an amide

Most harzadous substances exhibit a \"dose response relationship.\" What does this mean?

Which of the following is NOT a possible route of entry for a hazard?

A 10yr old boy has nocturnal enuresis. His patent takes him to a clinic that specializes in management of this condition. The physician writes an order to for a low dose imparamine. After a couple of weeks on the drug, depression of bed wetting decreased dramatically. What is a likely mechanism by which the imparamine provided benefit?

Which of the following statements is correct regarding benzodiazepines?

A 5 yr old boy consumed a liquid from a container in the family garage. He presents with CNS depression, obtunded reflexes, and ventilatory depression. A blood sample indicates profound metabolic acidosis, A check of the urine reveals crystals that are presumed to be oxalate. Which of the following is the most likely cause of the poisoning

Oxalate crystals in urine: This is a critical diagnostic feature of ethylene glycol poisoning. Oxalic acid is a metabolite of ethylene glycol, and calcium oxalate crystals can form in the urine and tissues. Let\'s briefly consider why the other options are less likely

Etomidate — which of this is not true?

Which of the following is not true of ketamine?

What factor does not influence the peak plasma levels after epidural injection of local anaesthetic?

Which ONE of the following is an amide?

Concerning the treatment of Parkinson\'s disease

Which of the following statements about Parkinson\'s disease is TRUE

Which of the following is UNTRUE of levodopa

The following are TRUE statements about antiparkisonian drugs Except

Which of the following statements concerning the pharmacological actions of opioids is UNTRUE

Which of the statements concerning the antidepressants is NOT true?

Which of the following statements best describes the difference between a sedative drug and a hypnotic

The pharmacological actions of benzodiazepines include all the following EXCEPT \*\*

Benzodiazepines are indicated in all the following conditions EXCEPT

For which of the following reasons are barbiturates still employed

Which of the following is UNTRUE concerning the pharmacological actions of opiods

Concerning the opioids which of the following is UNTRUE E]

All of the following are factors that affect the speed of induction and recovery of general anaesthesia EXCEPT

Which of the following statements is UNTRUE about the mechanism of action of local anaesthetics

Phenytoin, false statement

Concerning the side-effects of antipsychotic drugs, indicate the INCORRECT statement

Which of the following statements concerning the distribution of drugs from the blood into the CNS is true?

Like the benzodiazepines, the barbiturates

General statement concerning opioids is UNTRUE

Which Parkinsonism drug binds to dopamine receptors but does not affect dopamine action

Concerning opioids, which statement is TRUE

Tolerance occurs to the effects of opioids EXCEPT

Which of the following opioids is not an antitussive

A former drug abuser visits his physician to ask for pain medication for a legitimate back pain. The physician takes the takes the history of drug abuse into account. Which of the following medications has the greatest potential for abuse?

Which of the following drugs is an antitussive that is neither addicting nor constipating?

Which of the following opioid agonists is only administered by the parenteral route?

Which of the following is not associated with the development of a high degree of tolerance following opiate administration?

False statement about benzodiazepines

False statement about barbiturates

False statement about barbiturates

Treatment of opiod withdrawal symptoms

Mechanism of action of benzodiazepines

Which of the following best describes grand malepilepsy?

The following pharmacologic actions will be useful in epileptic conditions EXCEPT

Which is best suitable for the treatment of absence seizure?

The actions of anticonvulsants that block sodium channels are time-dependent because

Dental abnormality is most likely to be observed in children taking which of the following anticonvulsant?

Which drug will NOT affect the metabolism of 5-HT?

UNTRUE statement about Li

Which of the underlisted drugs will NOT alter the effects of Carbamazepine?

Which of the following is NOT related to the antidepressant mechanism of action of SSRIs?

Choose the correctly matched adverse effect(s) for the underlisted drugs ( This question was meant to say incorrect for it to be accurate)

Which local anaesthetic agents is a long duration ester

Protein binding of local anaesthetics (in decreasing order)

Which of the following inhalational anaesthetics is most likely to produce hepatotoxicity?

Which one of the following drugs is INCORRECTLY paired with its toxic effects?

Which of the following statements concerning Tetrahydrocannabinol (THC) is CORRECT?

A drug A is toxic. Drug B is not toxic when given several doses higher than drug A. On administering both drugs together, it results in a higher toxicity than drug A when given alone. This drug reaction is called

Which of the following statements is WRONG concerning atypical antipsychotics?

Which of the following antipsychotics causes agranulocytosis?

About antipsychotics drug action

Which one does not affect the rate of local anaesthetic function

Which of the following is not an effect of the venom poisoning of snake bite

Which of the following is false?

Wrong statement about partial agonists

Antiepileptic drugs do not act by which of the following mechanisms

Pinpoint pupils, depressed respiration, skin secretions and blood pressure. Implicated class of drug in this toxidrome

About toxidrome, which is NOT used to make a narrow differential diagnosis

A 10-year-old boy had nocturnal enuresis. His parents took him to a clinic that specializes in the management of this condition. The physician writes an order of low dose of imipramine. After a couple of weeks on the drug, the episode of bed wetting decreased dramatically. What is the most likely mechanism by which the imipramine provided benefit?

Tardive dyskinesia, wrong statement

Side effects of first-generation antipsychotics may be due to their interaction with?

Dissociative anaesthesia is associated with which of the following?

Regarding side effects of lithium

In the treatment of bipolar disorder which of the following class of drugs is not used

Concerning toxidrome, to allow rapid narrowing of the toxicologic differentials, one needs to rely on readily observable features such as the following except

Classical features of pin point pupils, depressed respiration, skin secretions and blood pressure are characteristic of what toxidrome?

Possible toxic effects of snake

Trihexyphenidyl is prescribed as an adjunct to other drugs being used to manage a patient with Parkinson disease. What is the most likely purpose or action of this drug as part of the overall drug treatment plan?

A patient with Parkinson disease starts therapy with a drug that acts in the CNS as an agonist for dopamine receptors. It has no direct effects on dopamine synthesis, neuronal reuptake, or metabolic inactivation. What drug fits this description the best?

A 10-year-old boy has nocturnal enuresis. His parents take him to a clinic that specializes in management of this condition. The physician writes an order for a low dose of imipramine. After a couple of weeks on the drug, the episodes of bed-wetting decrease dramatically. What is the most likely mechanism by which the imipramine provided benefit?

A Boko Haram terrorist drops a vial of \"nerve gas into a crowded subway at rush hour. The patients are brought to the nearest emergency centers and are given atropine. Which effect of the nerve gas will persist after administration of atropine?

In patients taking disulfiram, the unpleasant effects of ethanol ingestion result from

Both cocaine and amphetamine

A 66-year-old woman is diagnosed with Alzheimer disease, symptoms being described as minimal to moderate. What approach is generally consider most fruitful in terms of alleviating symptoms of early Alzheimer probably slowing the course underlying the brain

A patient who has been treated with levodopa is switched to a regimen with a product that contains levodopa plus carbidopa. What is the main action of carbidopa that provides the rationale for using it in this dual-drug approach?

Which of these statements about microbial toxin is incorrect?

The following actions of opioids are mediated by u-opioid receptors EXCEPT

Which of the following statements is FALSE?

Tolerance occurs to the all the following effects of opioids EXCEPT

Which of the following opioids is not normally administered as an antitussive

Which of the following is associated with abuse of opioid analgesics?

Which of the following opioid agonist is only administered by the parenteral route?

Which of the following statements concerning Phenytoin is INCORRECT?

All the following pharmacologic actions will be useful in epileptic conditions EXCEPT

Bromocriptine, FALSE statement

Benzodiazepines, FALSE statement

Which of the following drug toxicity pairs is INCORRECT?

Flumazenil, FALSE statement

For which one of the following drugs is the therapeutic indication INCORRECT?

An example of amide local anaesthetic

Which of the following mechanism of action is FALSE?

Barbiturates, CORRECT statement

Which of the following is not CORRECT?

Which of the inhalational anaesthetics is most likely to produce hepatotoxicity?

The phenothiazine which doesn\'t have any clinical antiemetic effect

Which is not a contraindication to Cycrimine [Pargitone] therapy

Tardive dyskinesia

Atypical neuroleptics

Like the benzodiazepines, Busprione

The nature of the phenothiazine side chain determines their

Correct statement is pg 215 of 4th ed Tarah and pg 491 0f 12th ed Kartzung

All thymoleptics

Non hydrazine inhibitors

Increased benzodiazepine doses [b] (pg 404 of Goodman and Gilman)

Which isn\'t a type of acquired parkinsonism

Which of the following is not associated with development of high degree of tolerance following opiate administration

A 10years old boy had nocturnal enuresis. His parents take him to a clinic that specializes in the management of this condition. The physician writes an order of low dose of imipramine. After a couple of weeks on drug,the episode of bed wetting decreased dramatically. What is the most likely mechanism by which the imipramine provided benefit?

Which of the following receptors is responsible for the analgesic and respiratory depression action of opioids

Snake venoms can cause the following Except

Pharmacokinetic blood level monitoring is apt to be most helpful for which of the following anticonvulsants?

A Patient you began on carbamazepine recently has returned to your office complaining of headache, vomiting, and dizziness. The patient is mildly confused. Laboratory data were: sodium 112 mEq/L, potassium 3.9 mEq/L, chloride 90 mEq/L, BUN 12 mg/dl and albumin 3.2 G/dl (normal values for lab: sodium 135-148, potassium 3.0-5.3, chloride 96-107, BUN 7-22, albumin 3.8-4.8). Which of the following best explains this patient\'s symptomatology?

Which of the following anticonvulsants is (are) administered as a single daily dose?

Since it\'s introduction in 1938, Phenytoin has been a major anticonvulsant drug in the treatment of epilepsy. Phenytoin therapy has been shown to be of value for which of the following seizure types?

Which of these drugs increases the steady state concentration of phenytoin?

Match the drug and effect - which is INCORRECT?

A patient on phenytoin has a seizure and is found to have a low level, which is least likely to cause this?

With rergard to phenytoin, which is NOT true?

A patient started on carbamazepine for episodes of partial seizures. After a month where she was seizure free, she started having further seizures. What is the MOST likely cause?

Your patient has abnormal LFTs, in particular an elevated AST. He tells you he is on medication for fits, but can't name it. Which is MOST likely to be his drug?

with regard to the general pharmacokinetics of anticonvulsants

concerning toxicity of phenytoin

Which of the following regarding carbemazepine is FALSE?

Patient on phenytoin is found to have a low blood phenytoin level. Which of the following is LEAST likely to cause this?

Regarding lithium

Regarding chlorpromazine which is NOT true?

Regarding the pharmacokinetics of Phenytoin, which is incorrect

Clinical uses of Valproate include the following, except

Regarding Carbamazepine, which of the following is true

Which is NOT a side effect of Phenytoin

Regarding Valproate, which is correct

Regarding phenytoin toxicity

Regarding adverse effects of propofol

Which of the following benzodiazepines has the shortest elimination half life

Which of the following side effects most occurs with haloperidol

Regarding non-depolarising muscle relaxants

Which of the following is a direct serotonin agonist

Methadone is used in the treatment of narcotic addiction because

Regarding the alcohols

Regarding inhaled anaesthetics, which is NOT true?

All of the following are anaesthetic agents EXCEPT

Regarding intravenous anaesthetics

Regarding adverse effects of propofol

Regarding local anaesthetics, which is incorrect

The following are all examples of amide local anaesthetics except

The following are all examples of ester local anaesthetics except

Regarding local anaesthetics, which is correct

Regarding the effects of local anaesthetics which is incorrect

Toxicity due to local anaesthetics includes all of the following except