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Year 4 pathway

Haematology / Immunology

Haematopoiesis, anaemias, haemostasis, malignancy, transfusion medicine, and clinical immunology. Every card is a launch point into the question bank and the grounded Teaching Room.

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1

Study day 1

Haematopoiesis and Red Cell Physiology

Introduction to haematology

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Haematopoiesis overview

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Erythropoiesis and erythropoietin

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Red blood cell biochemistry

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Red blood cell membrane

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Hereditary spherocytosis

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Hereditary elliptocytosis

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2

Study day 2

Iron, Folate and B12 Metabolism / Anaemias

Iron metabolism

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Iron deficiency anaemia

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Anaemia of chronic disease

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Iron overload

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Folate metabolism

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Vitamin B12 metabolism

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Megaloblastic anaemia

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Pernicious anaemia

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Investigating the anaemias

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Inherited haemolytic anaemias

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Acquired haemolytic anaemias

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3

Study day 3

Haemoglobinopathies

Haemoglobin structure, function and synthesis

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Haemoglobin variants

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Sickle cell anaemia I & II

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Alpha thalassaemia

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Beta thalassaemia

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4

Study day 4

Platelets and Coagulation

Thrombopoiesis and thrombopoietin

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Platelet physiology and thrombomimetics

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Thrombocytosis and thrombocytopenia

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Physiology of coagulation factors

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Introduction to the coagulation cascades

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Haemophilia A

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Haemophilia B

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Von Willebrand disease I & II

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Venous thromboembolism

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Anticoagulation therapy

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Thrombotic thrombocytopenic purpura / Haemolytic uraemic syndrome

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Disseminated intravascular coagulation

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Inherited thrombophilias

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Acquired thrombophilias

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Liver disease and bleeding disorder

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Immune thrombocytopenic purpura

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Haemorrhagic disease of the newborn

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5

Study day 5

Bone Marrow Failure and Myeloid Disorders

The spleen in haematology

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Pancytopenia

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Inherited bone marrow failure syndromes

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Acquired bone marrow failure syndromes: Aplastic anaemia

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Paroxysmal nocturnal haemoglobinuria

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Leukaemogenesis I & II

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Acute myeloid leukaemia

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Chronic myeloid leukaemia

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Myelodysplastic syndrome (MDS) I & II

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Polycythaemia vera

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Essential thrombocythaemia

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Primary myelofibrosis

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6

Study day 6

Lymphoid Malignancies

Acute lymphoblastic leukaemia

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Chronic lymphocytic leukaemia (diagnosis and treatment)

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Introduction to the lymphomas

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Hodgkin's lymphoma

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Non-Hodgkin's lymphoma

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Burkitt lymphoma

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Multiple myeloma

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7

Study day 7

Transfusion Medicine

ABO and Rh blood group systems

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Other blood group systems

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Indications for blood transfusion

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Blood donor selection

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Autologous blood donation/transfusion

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Massive blood loss / massive blood transfusion

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Complications of blood transfusion

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Blood component therapy and indications

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Management of blood transfusion-related reactions

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Introduction to haemovigilance

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Haemolytic disease of the newborn I & II

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8

Study day 8

Haematology in Special Populations and Clinical Practice

Haematology in pregnancy I & II

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Haematology in neonates I & II

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Haematological changes in systemic diseases

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Haematology in the elderly

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Haematological emergencies

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Supportive care in haematological malignancies

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Chemotherapy I & II (haemato-oncology)

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Introduction to haematopoietic stem cell transplantation (HSCT)

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Application of HSCT in haematology

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Introduction to gene therapy

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Application of gene therapy in haematology

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9

Study day 9

Basic Immunology

Introduction to immunology

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Innate immunity I & II

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Tolerance, immune paralysis and autoimmunity

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The lymphoid system / lymphoid organs

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Lymphopoiesis and plasma cell development

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Antibody production

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Antigens and immune response: antigenic determinants, factors affecting immune response, fate of antigens

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Tumour antigens

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Complement system I & II

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Immunoglobulin synthesis

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Immune tolerance

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HLA I & II

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10

Study day 10

Immune Dysregulation and Clinical Immunology

Immunosuppression I & II

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Immunology of immunodeficiency I & II

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Autoimmune disease I & II

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Autoimmune disorders with haematological involvement

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Immune haemolytic anaemias

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Immunoproliferative disorders

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Immunology of organ transplant I & II

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Immunology of malnutrition I & II

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Immunology of tropical parasitic, fungal, viral and bacterial diseases

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Human Immunodeficiency Virus (HIV) I & II

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